Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.32 |
| ▸ | CDK9 | P50750 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827920 | 0.82 | GCK (0.46) | KDM4EGCKTSHRMAPTHTT | |
| SCHEMBL1107397 | 0.79 | TSHR (0.38) | KDM4EGCKTSHRCCNT1CDK9 | |
| SCHEMBL1107380 | 0.78 | TSHR (0.36) | KDM4EGCKTSHRCCNT1CDK9 | |
| SCHEMBL1140072 | 0.77 | GCK (0.43) | KDM4EGCKCDK9MAPT | |
| SCHEMBL6061541 | 0.72 | TSHR (0.38) | KDM4EGCKTSHRMAPTHTT | |
| SCHEMBL12693702 | 0.72 | HCAR3 (0.34) | — | |
| SCHEMBL970301 | 0.71 | TSHR (0.36) | KDM4ETSHRMAPTHTTPPARD | |
| SCHEMBL17017353 | 0.71 | KDM4E (0.54) | KDM4ETSHRMAPTHTT | |
| SCHEMBL30563036 | 0.70 | GBA1 (0.41) | KDM4ETSHRMAPT | |
| SCHEMBL1106224 | 0.70 | GBA1 (0.41) | KDM4ETSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010013161-A1 | FLUORINATED HETEROARYLS | PFIZER INC. (US) | 2010-02-04 | — | — | WO | disclosed |