Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.65 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.65 |
| ▸ | KIT | P10721 | 5/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.65 |
| ▸ | FLT3 | P36888 | 3/20 | 0.65 |
| ▸ | CSF1R | P07333 | 3/20 | 0.65 |
| ▸ | EGFR | P00533 | 3/20 | 0.65 |
| ▸ | PLK4 | O00444 | 2/20 | 0.65 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.65 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.65 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.65 |
| ▸ | INSR | P06213 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19862518 | 0.86 | KDR (0.71) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL15459745 | 0.83 | KDR (0.74) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL13480222 | 0.83 | FLT3 (0.67) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL28430169 | 0.83 | KDR (0.74) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL9961043 | 0.82 | KDR (0.72) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL16569473 | 0.82 | KDR (0.72) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL9961038 | 0.81 | KDR (0.71) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL25600982 | 0.81 | KDR (0.71) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL9961042 | 0.81 | KDR (0.71) | KDRPDGFRBPRKAA1PRKAA2KIT | |
| SCHEMBL28428856 | 0.80 | KDR (0.83) | KDRPDGFRBPRKAA1PRKAA2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157093-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2010-02-24 | — | — | EP | disclosed |