Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.67 |
| ▸ | KDR | P35968 | 10/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.59 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.59 |
| ▸ | CSF1R | P07333 | 3/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.59 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.59 |
| ▸ | INSR | P06213 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12602180 | 0.85 | KDR (0.73) | FLT3KDRPDGFRBPRKAA1PRKAA2 | |
| SCHEMBL13480262 | 0.83 | KDR (0.65) | FLT3KDRPDGFRBPRKAA1PRKAA2 | |
| SCHEMBL29911476 | 0.81 | AKT2 (0.69) | FLT3KDRPDGFRBCSF1RKIT | |
| SCHEMBL22917527 | 0.81 | AKT2 (0.69) | FLT3KDRPDGFRBCSF1RKIT | |
| SCHEMBL28523144 | 0.80 | FLT3 (1.00) | FLT3KDRPDGFRBPRKAA1PRKAA2 | |
| SCHEMBL19862518 | 0.80 | KDR (0.71) | FLT3KDRPDGFRBPRKAA1PRKAA2 | |
| SCHEMBL29539755 | 0.80 | AKT2 (0.62) | FLT3KDRPDGFRBCSF1RALK | |
| SCHEMBL15459745 | 0.79 | KDR (0.74) | FLT3KDRPDGFRBPRKAA1PRKAA2 | |
| SCHEMBL28430169 | 0.79 | KDR (0.74) | FLT3KDRPDGFRBPRKAA1PRKAA2 | |
| SCHEMBL28540205 | 0.78 | FLT3 (0.85) | FLT3KDRPDGFRBPRKAA1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157093-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2010-02-24 | — | — | EP | disclosed |