Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 16/20 | 0.60 |
| ▸ | KDR | P35968 | 16/20 | 0.60 |
| ▸ | KIT | P10721 | 11/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480216 | 0.99 | PDGFRB (0.61) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL14449686 | 0.96 | PDGFRB (0.66) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3135101 | 0.91 | PDGFRB (0.62) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3135110 | 0.91 | PDGFRB (0.62) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3130037 | 0.90 | PDGFRB (0.60) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3130030 | 0.90 | PDGFRB (0.60) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3144593 | 0.89 | PDGFRB (0.61) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3144600 | 0.89 | PDGFRB (0.61) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL14450424 | 0.88 | PDGFRB (0.68) | PDGFRBKDRKITFGFR1SRC | |
| SCHEMBL154542 | 0.87 | PDGFRB (0.68) | PDGFRBKDRKITFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157093-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2010-02-24 | — | — | EP | disclosed |