Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 15/20 | 0.66 |
| ▸ | KDR | P35968 | 15/20 | 0.66 |
| ▸ | KIT | P10721 | 11/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480274 | 0.96 | PDGFRB (0.60) | PDGFRBKDRKITFGFR1AURKA | |
| SCHEMBL13480216 | 0.95 | PDGFRB (0.61) | PDGFRBKDRKITFGFR1AURKA | |
| SCHEMBL14450424 | 0.92 | PDGFRB (0.68) | PDGFRBKDRKITFGFR1CDK2 | |
| SCHEMBL137191 | 0.91 | PDGFRB (0.68) | PDGFRBKDRKITFGFR1CDK2 | |
| SCHEMBL154542 | 0.91 | PDGFRB (0.68) | PDGFRBKDRKITFGFR1CDK2 | |
| SCHEMBL151726 | 0.90 | PDGFRB (0.69) | PDGFRBKDRKITFGFR1CDK2 | |
| SCHEMBL138485 | 0.90 | PDGFRB (0.69) | PDGFRBKDRKITFGFR1CDK2 | |
| SCHEMBL139567 | 0.90 | KDR (0.66) | PDGFRBKDRKITFGFR1AURKA | |
| SCHEMBL155415 | 0.90 | KDR (0.66) | PDGFRBKDRKITFGFR1AURKA | |
| SCHEMBL155936 | 0.89 | KDR (0.67) | PDGFRBKDRKITFGFR1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973910-B1 | PYRROLO[3,2-C]PYRIDINE-4-ONE 2-INDOLINONE PROTEIN KINASE INHIBITORS | SHANGHAI HENGRUI PHARM CO LTD (CN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2007085188-A1 | PYRROLO [3,2-C] PYRIDINE-4-ONE 2-INDOLINONE PROTEIN KINASE INHIBITORS | SHANGHAI HENGRUI PHARMACEUTICAL CO. LTD. (CN) | 2007-08-02 | — | — | WO | disclosed |