Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169804 | 0.88 | HPGD (0.43) | HPGDALDH1A1SMN1; SMN2MAPK1HSP90AA1 | |
| SCHEMBL1169468 | 0.88 | SMN1; SMN2 (0.46) | HPGDALDH1A1SMN1; SMN2MAPK1HSP90AA1 | |
| SCHEMBL1168898 | 0.86 | SMN1; SMN2 (0.44) | HPGDALDH1A1SMN1; SMN2MAPK1HSP90AA1 | |
| SCHEMBL1169776 | 0.85 | HPGD (0.41) | HPGDALDH1A1SMN1; SMN2MAPK1HSP90AA1 | |
| SCHEMBL1168840 | 0.83 | ALDH1A1 (0.56) | HPGDALDH1A1SMN1; SMN2HSP90AA1LMNA | |
| SCHEMBL1168455 | 0.81 | PSEN1 (0.48) | HPGDSMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL1169186 | 0.81 | PSEN1 (0.48) | HPGDSMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL1168573 | 0.81 | MAPT (0.46) | ALDH1A1SMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL1169180 | 0.80 | SMN1; SMN2 (0.44) | HPGDSMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL1168532 | 0.80 | PSEN1 (0.47) | HPGDSMN1; SMN2MAPK1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063048-B2 | Acetylenyl-pyrazolo-pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |