Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | KLK7 | P49862 | 2/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24845246 | 0.97 | MAPT (0.70) | MAPTSYKKLK7KLK5HTT | |
| SCHEMBL24845372 | 0.92 | MAPT (0.64) | MAPTSYKKLK7KLK5HTT | |
| SCHEMBL28312630 | 0.90 | MAPT (0.57) | MAPTSYKKLK7KLK5HTT | |
| SCHEMBL28312629 | 0.90 | MAPT (0.57) | MAPTSYKKLK7KLK5HTT | |
| SCHEMBL16789691 | 0.89 | MAPT (0.63) | MAPTSYKKLK7KLK5HTT | |
| SCHEMBL5440929 | 0.88 | SYK (0.64) | MAPTSYKKLK7KLK5HTT | |
| SCHEMBL1374913 | 0.87 | MAPT (0.64) | MAPTSYKKLK7KLK5ITGB3 | |
| SCHEMBL1374918 | 0.87 | MAPT (0.64) | MAPTSYKKLK7KLK5ITGB3 | |
| SCHEMBL8955505 | 0.87 | KLK7 (0.64) | MAPTSYKKLK7KLK5HTT | |
| SCHEMBL2369249 | 0.87 | MAPT (0.64) | MAPTSYKKLK7KLK5ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655643-B2 | Antibacterial macrocycles with substituted biphenyl | AICURIS GMBH & CO. KG (DE) | 2010-02-02 | — | — | US | disclosed |