Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KLK7 | P49862 | 2/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24845246 | 0.95 | MAPT (0.70) | MAPTSYKL3MBTL1KLK7KLK5 | |
| SCHEMBL28312630 | 0.94 | MAPT (0.57) | MAPTSYKL3MBTL1KLK7KLK5 | |
| SCHEMBL28312629 | 0.94 | MAPT (0.57) | MAPTSYKL3MBTL1KLK7KLK5 | |
| SCHEMBL13480482 | 0.92 | MAPT (0.65) | MAPTSYKL3MBTL1KLK7KLK5 | |
| SCHEMBL5440929 | 0.92 | SYK (0.64) | MAPTSYKL3MBTL1KLK7KLK5 | |
| SCHEMBL30544856 | 0.88 | KLK7 (0.63) | MAPTSYKKLK7KLK5FOLH1 | |
| SCHEMBL2467817 | 0.88 | FOLH1 (0.65) | MAPTSYKKLK7KLK5FOLH1 | |
| SCHEMBL27497192 | 0.88 | KLK7 (0.63) | MAPTSYKKLK7KLK5FOLH1 | |
| SCHEMBL699636 | 0.88 | FOLH1 (0.65) | MAPTSYKKLK7KLK5FOLH1 | |
| SCHEMBL1491720 | 0.88 | FOLH1 (0.65) | MAPTSYKKLK7KLK5FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023275199-A1 | MACROCYCLIC TAK1 INHIBITORS | AQILION AB (SE) | 2023-01-05 | — | — | WO | disclosed |