Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.47 |
| ▸ | MAP3K8 | P41279 | 9/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480746 | 0.91 | EGFR (0.66) | EGFRERBB2MAP3K8 | |
| SCHEMBL13480787 | 0.83 | EGFR (0.50) | EGFRERBB2MAP3K8 | |
| SCHEMBL13480784 | 0.82 | EGFR (0.51) | EGFRERBB2MAP3K8 | |
| SCHEMBL13480789 | 0.81 | EGFR (0.54) | EGFRERBB2MAP3K8 | |
| SCHEMBL13481400 | 0.81 | EGFR (0.53) | EGFRERBB2 | |
| SCHEMBL13480747 | 0.81 | EGFR (0.51) | EGFRERBB2MAP3K8 | |
| SCHEMBL13480761 | 0.80 | EGFR (0.51) | EGFRERBB2MAP3K8 | |
| SCHEMBL13480792 | 0.79 | MAP3K8 (0.47) | EGFRERBB2MAP3K8 | |
| SCHEMBL3192981 | 0.79 | EGFR (0.67) | EGFRMAP3K8 | |
| SCHEMBL3193466 | 0.79 | EGFR (0.52) | EGFRERBB2MAP3K8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |