Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | MAP3K8 | P41279 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480787 | 0.90 | EGFR (0.50) | EGFRERBB2MAP3K8 | |
| SCHEMBL13481371 | 0.89 | EGFR (0.41) | EGFRERBB2MAP3K8LMNA | |
| SCHEMBL13480789 | 0.86 | EGFR (0.54) | EGFRERBB2MAP3K8MEN1KMT2A | |
| SCHEMBL13480792 | 0.84 | MAP3K8 (0.47) | EGFRERBB2MAP3K8 | |
| SCHEMBL13480746 | 0.82 | EGFR (0.66) | EGFRERBB2MAP3K8 | |
| SCHEMBL13480765 | 0.82 | EGFR (0.54) | EGFRERBB2MAP3K8 | |
| SCHEMBL3192981 | 0.81 | EGFR (0.67) | EGFRMAP3K8 | |
| SCHEMBL3193466 | 0.80 | EGFR (0.52) | EGFRERBB2MAP3K8 | |
| SCHEMBL13480745 | 0.79 | EGFR (0.69) | EGFRERBB2MAP3K8 | |
| SCHEMBL3195945 | 0.78 | EGFR (0.50) | EGFRERBB2MAP3K8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |