Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.46 |
| ▸ | ABL1 | P00519 | 5/20 | 0.42 |
| ▸ | ABL2 | P42684 | 5/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | AGER | Q15109 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13481401 | 0.86 | SRC (0.36) | SRCABL1ABL2EGFRFGFR4 | |
| SCHEMBL13481403 | 0.83 | SRC (0.39) | SRCABL1ABL2HRH3ZAP70 | |
| SCHEMBL13480800 | 0.82 | SRC (0.36) | SRCABL1ABL2EGFRFGFR4 | |
| SCHEMBL13480798 | 0.81 | SRC (0.52) | SRCABL1ABL2KDR | |
| SCHEMBL13480805 | 0.78 | ABL1 (0.38) | SRCABL1ABL2HRH3ZAP70 | |
| SCHEMBL13480808 | 0.76 | SRC (0.41) | SRCABL1ABL2EGFRKDR | |
| SCHEMBL13481402 | 0.76 | SRC (0.43) | SRCABL1ABL2EGFRMAP2K1 | |
| SCHEMBL13480803 | 0.75 | EGFR (0.35) | SRCABL1ABL2HRH3EGFR | |
| SCHEMBL13481384 | 0.75 | SRC (0.37) | SRCABL1ABL2EGFRFGFR4 | |
| SCHEMBL13481385 | 0.74 | KDM1A (0.35) | SRCABL1ABL2EGFRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |