Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.35 |
| ▸ | SRC | P12931 | 5/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ABL2 | P42684 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 7/20 | 0.34 |
| ▸ | MYLK | Q15746 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | FLT4 | P35916 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13481384 | 0.92 | SRC (0.37) | EGFRSRCLCKABL1ABL2 | |
| SCHEMBL13480805 | 0.82 | ABL1 (0.38) | EGFRSRCABL1ABL2KDM1A | |
| SCHEMBL13481385 | 0.82 | KDM1A (0.35) | EGFRSRCLCKABL1ABL2 | |
| SCHEMBL13481403 | 0.79 | SRC (0.39) | EGFRSRCLCKABL1ABL2 | |
| SCHEMBL13480800 | 0.77 | SRC (0.36) | EGFRSRCLCKABL1ABL2 | |
| SCHEMBL13481402 | 0.76 | SRC (0.43) | EGFRSRCLCKABL1ABL2 | |
| SCHEMBL13480798 | 0.76 | SRC (0.52) | SRCABL1ABL2KDR | |
| SCHEMBL13480799 | 0.75 | SRC (0.46) | EGFRSRCABL1ABL2HRH3 | |
| SCHEMBL13481401 | 0.75 | SRC (0.36) | EGFRSRCLCKABL1ABL2 | |
| SCHEMBL13480808 | 0.72 | SRC (0.41) | EGFRSRCLCKABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |