Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amoxicillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | RARB | P10826 | 1/20 | 1.00 |
| ▸ | RARG | P13631 | 1/20 | 1.00 |
| ▸ | NR1H2 | P55055 | 1/20 | 1.00 |
| ▸ | NR1H3 | Q13133 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.84 |
| ▸ | HPGD | P15428 | 3/20 | 0.84 |
| ▸ | POLB | P06746 | 2/20 | 0.84 |
| ▸ | MEN1 | O00255 | 1/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.84 |
| ▸ | TEK | Q02763 | 1/20 | 0.84 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.84 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.70 |
| ▸ | GLA | P06280 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amoxicillin SCHEMBL2636892 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL3427 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL18872879 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL13662733 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL13105238 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL24768939 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL226659 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL11378022 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL22380860 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL15387744 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666398-B2 | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2010-02-23 | — | — | US | disclosed |
| US-7666398-B2 | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2010-02-23 | — | — | US | disclosed |