Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amoxicillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | RARB | P10826 | 1/20 | 1.00 |
| ▸ | RARG | P13631 | 1/20 | 1.00 |
| ▸ | NR1H2 | P55055 | 1/20 | 1.00 |
| ▸ | NR1H3 | Q13133 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.84 |
| ▸ | HPGD | P15428 | 3/20 | 0.84 |
| ▸ | POLB | P06746 | 2/20 | 0.84 |
| ▸ | MEN1 | O00255 | 1/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.84 |
| ▸ | TEK | Q02763 | 1/20 | 0.84 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.84 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.70 |
| ▸ | GLA | P06280 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amoxicillin SCHEMBL2636892 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL13481266 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL18872879 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL13662733 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL13105238 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL24768939 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL226659 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL11378022 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL22380860 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 | |
| Amoxicillin SCHEMBL15387744 | 1.00 | KDM4E (1.00) | KDM4ELMNARARBRARGNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 128081 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747263-A1 | LIPID NANOPARTICLES AND USES THEREOF | University of Connecticut (US) | 2026-05-27 | — | — | EP | claimed |
| US-12637481-B2 | Boronic acid derivatives and therapeutic uses thereof | QPEX BIOPHARMA, INC. (US) | 2026-05-26 | — | — | US | claimed |
| CN-122075430-A | Amoxicillin capsule and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121754734-B | Silk fibroin-based bionic artificial tympanic membrane with gradient structure and preparation method thereof | Fuxiang Sitai medical technology (Suzhou) Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| WO-2026107208-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | THE METHODIST HOSPITAL (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| WO-2026104587-A1 | CYCLIC BORONIC ACID ESTERS USEFUL AS ADJUVANTS IN THE TREATMENT OF BACTERIAL INFECTIONS | ADJUTEC PHARMA AS (NO) | 2026-05-21 | — | — | WO | claimed |
| WO-2026106551-A1 | ANTIMICROBIAL PEPTIDE NANONETS AND METHODS OF USE THEREOF | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2026-05-21 | — | — | WO | claimed |
| EP-4743122-A1 | THERAPEUTIC SEALANTS BASED UPON DRUG CONJUGATES | The Johns Hopkins University (US) | 2026-05-20 | — | — | EP | claimed |
| EP-0001333-A1 | Clavulanic acid derivatives, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1979-04-04 | — | — | EP | claimed |
| US-4145429-A | VEGETALBE OIL, CLAY, ANTIBIOTIC | BEECHAM GROUP LIMITED (GB) | 1979-03-20 | — | — | US | claimed |
| US-4143134-A | BACTERICIDES, ANTIBIOTIC POTENTIATORS | HOFFMANN-LA ROCHE INC. (US) | 1979-03-06 | — | — | US | claimed |
| US-4140764-A | ISOCLAVULANIC ACID OR SALT, OXAPENICILLINS IN COMBINATION WITH PENCILLINS OR CEPHALOSPORINS | BEECHAM GROUP LIMITED (GB) | 1979-02-20 | — | — | US | claimed |
| US-4128547-A | TERTIARY AMINE CATALYST | GIST-BROCADES N.V. (NL) | 1978-12-05 | — | — | US | claimed |
| US-4073687-A | PENICILLINS OR CEPHALOSPORINS | SHIONOGI & CO., LTD. (JA) | 1978-02-14 | — | — | US | claimed |
| US-4005214-A | CHOLINE, BACTERICIDE | HOFFMANN-LA ROCHE INC. (US) | 1977-01-25 | — | — | US | claimed |
| US-3996355-A | SACCHARIDE, VEGETABLE OIL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-12-07 | — | — | US | claimed |
| US-3980637-A | ACYLATION OF SILYLATED 6-AMINOPENICILLANIC ACID WITH 2-PARA-HYDROXY-PHENYLGLYCINE CHLORIDE HYDROCHLORIDE | BRISTOL-MYERS COMPANY (US) | 1976-09-14 | — | — | US | claimed |
| US-3969524-A | Stable amoxicillin dosage form | HOFFMANN-LA ROCHE INC. (US) | 1976-07-13 | — | — | US | claimed |