Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 1.00 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.56 |
| ▸ | CALCA | P06881 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13481982 | 0.83 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| SCHEMBL13481980 | 0.82 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| SCHEMBL13481978 | 0.82 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| SCHEMBL3188889 | 0.78 | CALCRL (1.00) | CALCRL | |
| SCHEMBL13481981 | 0.78 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| SCHEMBL3608876 | 0.78 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| SCHEMBL3608883 | 0.78 | CALCRL (1.00) | CALCRLRAMP1CALCA | |
| SCHEMBL19236114 | 0.78 | CALCRL (0.81) | CALCRLRAMP1CALCA | |
| SCHEMBL2766016 | 0.77 | CALCRL (0.74) | CALCRLRAMP1CALCA | |
| SCHEMBL4213464 | 0.76 | CALCRL (1.00) | CALCRLRAMP1CALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799672-B1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-01-02 | — | — | EP | disclosed |
| US-7659264-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-02-09 | — | — | US | disclosed |
| US-7659264-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-02-09 | — | — | US | disclosed |
| US-20080070899-A1 | Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2008-03-20 | — | — | US | disclosed |
| US-20080070899-A1 | Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070899-A1 | Cgrp Receptor Antagonists | BDKRB1, CCKBR, CALCRL | CALCRL 3/4885RAMP1 129/4885CALCA 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.