Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484133 | 0.77 | HSD17B10 (0.40) | HSD17B10PRKCAGAALMNAKDM4E | |
| SCHEMBL22504172 | 0.66 | HSD17B10 (0.32) | HSD17B10 | |
| SCHEMBL5844011 | 0.62 | HSD17B10 (0.46) | HSD17B10KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL22335435 | 0.60 | HSD17B10 (0.35) | HSD17B10GAAKDM4EPKM | |
| SCHEMBL21895353 | 0.58 | CRBN (0.33) | HSD17B10LMNAKDM4E | |
| SCHEMBL22783789 | 0.58 | PIK3CD (0.38) | — | |
| SCHEMBL22993753 | 0.56 | PIK3CD (0.39) | — | |
| SCHEMBL901435 | 0.56 | — | — | |
| SCHEMBL1359080 | 0.56 | GAA (0.39) | HSD17B10GAALMNAKDM4EPKM | |
| SCHEMBL1802571 | 0.55 | HSD17B10 (0.42) | HSD17B10LMNAKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41149-E1 | Stereoisomerically pure 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid or a pharmaceutically acceptable salt thereof; antibacterial agents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |