Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.63 |
| ▸ | MLYCD | O95822 | 1/20 | 0.63 |
| ▸ | MMP13 | P45452 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17847319 | 0.95 | HDAC6 (0.57) | HDAC6MLYCDMMP13POLBCA2 | |
| SCHEMBL17847332 | 0.92 | MAPK14 (0.57) | HDAC6MLYCDMMP13POLBCA2 | |
| SCHEMBL10722498 | 0.89 | HDAC6 (0.77) | HDAC6MLYCDMMP13POLBCA2 | |
| SCHEMBL507994 | 0.85 | HDAC6 (0.63) | HDAC6MLYCDMMP13POLBCA2 | |
| SCHEMBL9546920 | 0.85 | HDAC6 (0.63) | HDAC6MLYCDMMP13POLBCA2 | |
| SCHEMBL9546986 | 0.84 | MMP13 (0.84) | HDAC6MLYCDMMP13POLBCA2 | |
| SCHEMBL8389571 | 0.83 | HDAC6 (0.68) | HDAC6MLYCDMMP13POLBCA2 | |
| SCHEMBL17483892 | 0.83 | HDAC6 (0.70) | HDAC6MLYCDMMP13POLBCA2 | |
| SCHEMBL13483889 | 0.82 | HDAC6 (0.68) | HDAC6MLYCDMMP13POLBCA2 | |
| Methyl Alcohol SCHEMBL11518093 | 0.81 | SMN1; SMN2 (0.72) | HDAC6MLYCDMMP13POLBCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7667036-B2 | MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) inhibitors; inflammatory, autoimmune disease, destructive bone disorder, cancer and/or tumor growth; angiogenesis, diabetes and neurological disorders | TEIJIN PHARMA LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |