Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13315223 | 0.83 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13487547 | 0.80 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13487575 | 0.79 | RPS6KB1 (0.55) | MAPK14MAPK13MAPK12MAPK11RPS6KB1 | |
| SCHEMBL13487556 | 0.79 | MAPK14 (0.38) | MAPK14MAPK13MAPK12MAPK11RPS6KB1 | |
| SCHEMBL3546814 | 0.76 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11RPS6KB1 | |
| SCHEMBL4090663 | 0.76 | CNR2 (0.45) | MAPK14MAPK13MAPK12MAPK11RPS6KB1 | |
| SCHEMBL13315098 | 0.75 | YEATS4 (0.50) | MAPK14MAPK13MAPK12MAPK11RPS6KB1 | |
| SCHEMBL3549267 | 0.73 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11RPS6KB1 | |
| SCHEMBL3543989 | 0.72 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11RPS6KB1 | |
| SCHEMBL3547903 | 0.72 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041642-A1 | UREA INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041642-A1 | UREA INHIBITORS OF MAP KINASES | MAP4K2, MAP3K1, MAP3K20 | MAPK14 33/4885MAPK13 44/4885MAPK12 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.