Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30887591 | 0.84 | ACE (0.60) | MMP1MMP3MMP9ACECTSS | |
| SCHEMBL30291800 | 0.84 | ACE (0.60) | MMP1MMP3MMP9ACECTSS | |
| SCHEMBL27706581 | 0.83 | CASP1 (0.50) | MMP1MMP3MMP9ACECTSK | |
| SCHEMBL2063189 | 0.83 | CASP1 (0.50) | MMP1MMP3MMP9ACECTSK | |
| SCHEMBL10166824 | 0.82 | SYK (0.54) | CTSKCTSSMAPT | |
| SCHEMBL30649083 | 0.82 | SYK (0.54) | CTSKCTSSMAPT | |
| SCHEMBL18882492 | 0.80 | TRPV1 (0.49) | MMP1MMP3MMP9CTSKPAX8 | |
| SCHEMBL18645311 | 0.79 | TRPV1 (0.50) | MMP1MMP3MMP9ACECTSK | |
| SCHEMBL5970655 | 0.79 | SYK (0.55) | CTSKCTSSMAPT | |
| SCHEMBL7222412 | 0.79 | SYK (0.55) | CTSKCTSSMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017035-A2 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2010-02-11 | — | — | WO | disclosed |