Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12057965 | 0.84 | SYK (0.43) | IRAK4CCNT1PRKCAPRKCQCYP1A2 | |
| SCHEMBL12037652 | 0.84 | IRAK4 (0.58) | IRAK4 | |
| SCHEMBL13493553 | 0.71 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL13493704 | 0.68 | IRAK4 (0.36) | IRAK4 | |
| SCHEMBL12058252 | 0.67 | IRAK4 (0.36) | IRAK4MAPT | |
| SCHEMBL12058354 | 0.67 | IRAK4 (0.37) | IRAK4 | |
| SCHEMBL12058119 | 0.66 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL13493549 | 0.66 | IRAK4 (0.48) | IRAK4MAPTADORA1 | |
| SCHEMBL13493530 | 0.65 | IRAK4 (0.52) | IRAK4 | |
| SCHEMBL12058488 | 0.64 | IRAK4 (0.71) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022121-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | SCHERING CORPORATION (US) | 2010-02-25 | — | — | WO | disclosed |