Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13026587 | 0.92 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL13026579 | 0.84 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL11934779 | 0.84 | CCNK (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL13438663 | 0.84 | CCNK (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL12921211 | 0.76 | SMN1; SMN2 (0.57) | RAB9ANPC1SMN1; SMN2ALDH1A1GRM5 | |
| SCHEMBL13565931 | 0.75 | NPC1 (0.40) | RAB9ANPC1SMN1; SMN2ALDH1A1SCD | |
| SCHEMBL13564740 | 0.75 | NPC1 (0.42) | RAB9ANPC1SMN1; SMN2ALDH1A1SCD | |
| SCHEMBL17089947 | 0.75 | NPC1 (0.42) | RAB9ANPC1SMN1; SMN2ALDH1A1SCD | |
| SCHEMBL29438377 | 0.75 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL29438374 | 0.75 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015655-A1 | CYCLOHEXYL AMIDE DERIVATIVES AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |