SCHEMBL13495646

SCHEMBL13495646

C=C(Oc1ccc([N+](=O)[O-])cc1)[C@@H](CC(C)C)NC(=O)OC(C)(C)C

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.57
MAPT P10636 4/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
NPC1 O15118 2/20 0.57
RAB9A P51151 2/20 0.57
NPSR1 Q6W5P4 1/20 0.57
GAA P10253 3/20 0.56
PPARG P37231 1/20 0.48
PPARA Q07869 1/20 0.48
AAK1 Q2M2I8 1/20 0.44
CTSL P07711 2/20 0.42
MGLL Q99685 2/20 0.42
CTSB P07858 1/20 0.42
CTSS P25774 1/20 0.42
CTSK P43235 1/20 0.42
BCL9 O00512 1/20 0.41
CTNNB1 P35222 1/20 0.41
MAP1LC3B Q9GZQ8 1/20 0.40
MAP1LC3A Q9H492 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1935058 0.89 MAPT (0.66) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL1935059 0.89 MAPT (0.66) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL5434236 0.89 MAPT (0.66) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL6624647 0.84 MAPT (0.59) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL20631080 0.84 MAPT (0.59) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL31591663 0.80 ALDH1A1 (0.55) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL29006919 0.80 AAK1 (0.55) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL29006922 0.80 AAK1 (0.55) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL8171177 0.80 ALDH1A1 (0.54) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL12214497 0.79 PPARG (0.54) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010020055-A1 SMALL MOLECULE INHIBITORS OF N-TERMINUS ACTIVATION OF THE ANDROGEN RECEPTOR BRITISH COLUMBIA CANCER AGENCY BRANCH (CA) 2010-02-25 WO disclosed