Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 9/20 | 0.44 |
| ▸ | KLRK1 | P26718 | 2/20 | 0.43 |
| ▸ | MICA | Q29983 | 2/20 | 0.43 |
| ▸ | RAET1L | Q5VY80 | 2/20 | 0.43 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.42 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.42 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.42 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.42 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.42 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.42 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.42 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.42 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.42 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.42 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348590 | 0.92 | SLC6A9 (0.49) | SLC6A9KLRK1MICARAET1LCES2 | |
| SCHEMBL3241393 | 0.90 | SLC6A9 (0.49) | SLC6A9KLRK1MICARAET1LCES2 | |
| SCHEMBL1349793 | 0.89 | SLC6A9 (0.52) | SLC6A9 | |
| SCHEMBL3234829 | 0.88 | SLC6A9 (0.49) | SLC6A9KLRK1MICARAET1LCES2 | |
| SCHEMBL1350222 | 0.88 | SLC6A9 (0.49) | SLC6A9KLRK1MICARAET1LENPP2 | |
| SCHEMBL1348399 | 0.88 | SLC6A9 (0.50) | SLC6A9KLRK1MICARAET1LENPP2 | |
| SCHEMBL1349999 | 0.87 | SLC6A9 (0.50) | SLC6A9KLRK1MICARAET1LENPP2 | |
| SCHEMBL1350744 | 0.86 | KLRK1 (0.50) | SLC6A9KLRK1MICARAET1L | |
| SCHEMBL1349947 | 0.85 | KLRK1 (0.41) | SLC6A9KLRK1MICARAET1LENPP2 | |
| SCHEMBL1350402 | 0.85 | MTTP (0.45) | SLC6A9KLRK1MICARAET1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063098-B2 | GlyT1 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063098-B2 | GlyT1 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063098-B2 | GlyT1 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100048531-A1 | GlyT1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100048531-A1 | GlyT1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100048531-A1 | GlyT1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048531-A1 | GlyT1 RECEPTOR ANTAGONISTS | GLRA1, GLRA2, GRIA1 | SLC6A9 20/4885KLRK1 1606/4885MICA 2450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.