Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531398 | 0.83 | SMYD2 (0.34) | SMYD2 | |
| SCHEMBL3535876 | 0.83 | GRM5 (0.37) | SMYD2 | |
| SCHEMBL13499977 | 0.79 | HTR2C (0.32) | — | |
| SCHEMBL3537044 | 0.73 | SMN1; SMN2 (0.42) | SMYD2 | |
| SCHEMBL28723954 | 0.66 | SMYD2 (0.35) | SMYD2 | |
| SCHEMBL22247591 | 0.65 | RIPK1 (0.33) | SMYD2 | |
| SCHEMBL13696122 | 0.64 | SMYD2 (0.32) | SMYD2 | |
| SCHEMBL23528479 | 0.63 | SMYD2 (0.36) | SMYD2 | |
| SCHEMBL16259098 | 0.63 | SMYD2 (0.36) | SMYD2 | |
| SCHEMBL15018595 | 0.63 | SMYD2 (0.36) | SMYD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662811-B2 | N-(((5R)-5-((1-methylethyl)amino)-5,6,7,8-tetrahydro-2-naphthalenyl)methyl)-2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-1,2,3,4-tetrahydro-2-pyrazinyl)acetamide; for treatment of pain and diseases, such as inflammation mediated diseases | AMGEN INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-7612060-B2 | Triazoles and methods of use | AMGEN INC. (US) | 2009-11-03 | — | — | US | disclosed |