6Beta-Hydroxytestosterone

6Beta-Hydroxytestosterone

SCHEMBL135030

C[C@]12CC[C@H]3[C@@H](C[C@@H](O)C4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 1.00
CYP19A1 P11511 12/20 0.80
SHBG P04278 3/20 0.80
AR P10275 5/20 0.79
LMNA P02545 3/20 0.67
HSD17B10 Q99714 3/20 0.67
SERPINA6 P08185 3/20 0.67
NR3C1 P04150 2/20 0.67
PGR P06401 2/20 0.67
TSHR P16473 2/20 0.67
SNCA P37840 2/20 0.67
CACNA1C Q13936 2/20 0.67
CYP51A1 Q16850 2/20 0.67
GPBAR1 Q8TDU6 2/20 0.67
SIGMAR1 Q99720 2/20 0.67
MAPT P10636 1/20 0.67
MAPK1 P28482 1/20 0.67
OR51E2 Q9H255 1/20 0.67
ESR2 Q92731 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6Beta-Hydroxytestosterone SCHEMBL4122472 1.00 CYP3A4 (1.00) CYP3A4CYP19A1SHBGARLMNA
6Beta-Hydroxytestosterone SCHEMBL3278189 1.00 CYP3A4 (1.00) CYP3A4CYP19A1SHBGARLMNA
6Beta-Hydroxytestosterone SCHEMBL14067596 1.00 CYP3A4 (1.00) CYP3A4CYP19A1SHBGARLMNA
6Beta-Hydroxytestosterone SCHEMBL28056047 1.00 CYP3A4 (1.00) CYP3A4CYP19A1SHBGARLMNA
6Beta-Hydroxytestosterone SCHEMBL127408 1.00 CYP3A4 (1.00) CYP3A4CYP19A1SHBGARLMNA
6Beta-Hydroxytestosterone SCHEMBL13752809 1.00 CYP3A4 (1.00) CYP3A4CYP19A1SHBGARLMNA
SCHEMBL11524096 0.89 CYP19A1 (1.00) CYP3A4CYP19A1SHBGARLMNA
SCHEMBL6006777 0.89 CYP19A1 (1.00) CYP3A4CYP19A1SHBGARLMNA
SCHEMBL10273241 0.89 CYP19A1 (1.00) CYP3A4CYP19A1SHBGARLMNA
SCHEMBL5021333 0.89 CYP19A1 (1.00) CYP3A4CYP19A1SHBGARLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 409 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117849198-A UPLC-MS/MS analysis and detection method for 6 beta-hydroxytestosterone concentration in liver microsome system 江苏鼎泰药物研究(集团)股份有限公司 2024-04-09 CN claimed
US-20120111795-A1 DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2012-05-10 US claimed
EP-2421954-A1 DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS Academisch Ziekenhuis bij de Universiteit van Amsterdam (NL) 2012-02-29 EP claimed
WO-2010123357-A1 DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-10-28 WO claimed
US-20090117612-A1 METHOD OF BIOOXIDATION USING AN OLD YELLOW ENZYME GLIEDER ANTON 2009-05-07 US claimed
US-20090117613-A1 Method for redox reaction using an old yellow enzyme GLIEDER ANTON 2009-05-07 US claimed
WO-2008143956-A1 METHOD FOR REDOX REACTION USING AN OLD YELLOW ENZYME CODEXIS, INC. (US) 2008-11-27 WO claimed
WO-2008137789-A1 METHOD OF BIOOXIDATION USING AN OLD YELLOW ENZYME CODEXIS, INC. (US) 2008-11-13 WO claimed
EP-3998073-B1 DEVICES AND METHODS FOR SIMULATING A FUNCTION OF A LIVER TISSUE EMULATE INC (US) 2024-11-06 EP disclosed
EP-3383996-B1 DEVICES FOR SIMULATING A FUNCTION OF A LIVER TISSUE AND METHODS OF USE AND MANUFACTURING THEREOF HARVARD COLLEGE (US) 2024-10-16 EP disclosed
CN-118286194-A New use of glycine in preparing medicament or product for treating spermatogenic dysfunction 北京工商大学 2024-07-05 CN disclosed
WO-2024112853-A1 COMPOUNDS THAT INHIBIT PKMYT1 EXELIXIS, INC. (US) 2024-05-30 WO disclosed
CN-117849198-A UPLC-MS/MS analysis and detection method for 6 beta-hydroxytestosterone concentration in liver microsome system 江苏鼎泰药物研究(集团)股份有限公司 2024-04-09 CN disclosed
CN-117849198-A UPLC-MS/MS analysis and detection method for 6 beta-hydroxytestosterone concentration in liver microsome system 江苏鼎泰药物研究(集团)股份有限公司 2024-04-09 CN disclosed
US-5595997-A FEWER SIDE EFFECTS THAN WITH OTHER NON-SEDATING ANTIHISTAMINES SEPRACOR INC. (US) 1997-01-21 US disclosed
US-5429948-A Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays GENTEST CORPORATION (US) 1995-07-04 US disclosed
EP-0555315-A4 HUMAN CELL LINE STABLY EXPRESSING 5CDNAS ENCODING PROCARCINOGEN-ACTIVATING ENZYMES GENTEST CORP (US) 1994-08-17 EP disclosed
EP-0555315-A1 HUMAN CELL LINE STABLY EXPRESSING 5cDNAs ENCODING PROCARCINOGEN-ACTIVATING ENZYMES GENTEST CORPORATION (US) 1993-08-18 EP disclosed
WO-1992007085-A1 HUMAN CELL LINE STABLY EXPRESSING 5cDNAs ENCODING PROCARCINOGEN-ACTIVATING ENZYMES GENTEST CORPORATION (US) 1992-04-30 WO disclosed
US-4874696-A FROM ALCALIGENES; MEDICAL DIAGNOSIS THE JOHNS HOPKINS UNIVERSITY, MED SCHOOL (US) 1989-10-17 US disclosed