Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIOK2 | Q9BVS4 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13788645 | 0.91 | MAPK14 (0.47) | RIOK2MAPK14MAPK10ALDH1A1SMN1; SMN2 | |
| SCHEMBL12281841 | 0.87 | MAPK14 (0.51) | RIOK2MAPK14GCKMTNR1AMTNR1B | |
| SCHEMBL13504171 | 0.87 | KMT2A (0.46) | RIOK2MAPK14MAPK10ALDH1A1SMN1; SMN2 | |
| SCHEMBL13504168 | 0.87 | GCK (0.50) | RIOK2MAPK14MAPK10ALDH1A1SMN1; SMN2 | |
| SCHEMBL14656542 | 0.84 | HDAC3 (0.47) | MAPK14GCKKDR | |
| SCHEMBL14656101 | 0.84 | MAPK14 (0.44) | RIOK2MAPK14MAPK10ALDH1A1SMN1; SMN2 | |
| SCHEMBL13504234 | 0.84 | KDR (0.47) | RIOK2MAPK14MAPK10ALDH1A1SMN1; SMN2 | |
| SCHEMBL13504162 | 0.82 | LMNA (0.58) | RIOK2MAPK14ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13504157 | 0.82 | RIOK2 (0.47) | RIOK2MAPK14MAPK10ALDH1A1SMN1; SMN2 | |
| SCHEMBL13504268 | 0.81 | POLB (0.53) | MAPK14ALDH1A1SMN1; SMN2GCKMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370429-B1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD (GB) | 2016-04-20 | — | — | EP | disclosed |
| US-8299074-B2 | P38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2012-10-30 | — | — | US | disclosed |
| US-20110312963-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD (GB) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312963-A1 | P38 MAP KINASE INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | RIOK2 761/4885MAPK14 25/4885MAPK10 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.