Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23266636 | 0.85 | HTT (0.60) | POLBHTTFGFR1MKNK1MKNK2 | |
| SCHEMBL3417306 | 0.79 | HTT (0.73) | POLBHTTFGFR1MKNK1MKNK2 | |
| SCHEMBL27995809 | 0.79 | HTT (0.58) | POLBMAPTKMT2ANPSR1HTT | |
| SCHEMBL23266681 | 0.79 | HTT (0.53) | POLBHTTFGFR1MKNK1MKNK2 | |
| SCHEMBL18892144 | 0.76 | MAPT (0.51) | POLBCYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL21135010 | 0.75 | HTT (0.49) | POLBHTTFGFR1MKNK1MKNK2 | |
| SCHEMBL21135011 | 0.75 | HTT (0.49) | POLBHTTFGFR1MKNK1MKNK2 | |
| SCHEMBL23266691 | 0.75 | HTT (0.53) | POLBMAPTKMT2ANPSR1HTT | |
| SCHEMBL30389764 | 0.75 | HTT (0.49) | POLBHTTFGFR1MKNK1MKNK2 | |
| SCHEMBL25635315 | 0.75 | HTT (0.49) | POLBHTTFGFR1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2319837-B1 | Benzimidazole derivatives and their use for modulating the GABAa receptor complex | NEUROSEARCH AS (DK) | 2012-10-31 | — | — | EP | disclosed |