Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 4/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | DHODH | Q02127 | 4/20 | 0.56 |
| ▸ | PARP1 | P09874 | 3/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | METAP2 | P50579 | 2/20 | 0.51 |
| ▸ | METAP1 | P53582 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | WNT1 | P04628 | 3/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14645905 | 0.88 | CBFB (0.65) | CBFBAURKADHODHPARP1PARP2 | |
| SCHEMBL31027957 | 0.82 | DHODH (0.59) | DHODHPARP1ALDH1A1CYP2D6NPC1 | |
| SCHEMBL7146754 | 0.81 | DHODH (0.62) | DHODHPARP1ALDH1A1CYP2D6NPC1 | |
| SCHEMBL13504644 | 0.78 | NPC1 (0.50) | CBFBAURKAPARP1SMN1; SMN2HPGD | |
| SCHEMBL6677672 | 0.78 | CBFB (0.44) | CBFBAURKADHODHPARP1PARP2 | |
| SCHEMBL1170898 | 0.77 | DHODH (0.54) | DHODHPARP1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL4457030 | 0.76 | DHODH (0.53) | DHODHPARP1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL230979 | 0.76 | DHODH (0.53) | DHODHPARP1CYP2D6NPC1RAB9A | |
| SCHEMBL18438773 | 0.76 | CLK2 (0.61) | CBFBWNT1TGFBR1 | |
| SCHEMBL5051916 | 0.76 | MGAM (0.56) | DHODHPARP1PARP2GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2319837-B1 | Benzimidazole derivatives and their use for modulating the GABAa receptor complex | NEUROSEARCH AS (DK) | 2012-10-31 | — | — | EP | disclosed |