Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.37 |
| ▸ | PFKFB4 | Q16877 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3685641 | 1.00 | PFKFB3 (0.37) | PFKFB3PFKFB4ALDH1A1MAPK1SLC2A1 | |
| SCHEMBL13508409 | 0.93 | PPARD (0.40) | PFKFB3PFKFB4SLC2A1CMA1 | |
| SCHEMBL13508288 | 0.93 | PPARD (0.40) | PFKFB3PFKFB4SLC2A1CMA1 | |
| SCHEMBL3679124 | 0.93 | PPARD (0.40) | PFKFB3PFKFB4SLC2A1CMA1 | |
| SCHEMBL3684587 | 0.92 | PFKFB3 (0.38) | PFKFB3PFKFB4ALDH1A1MAPK1SLC2A1 | |
| SCHEMBL3688989 | 0.92 | PFKFB3 (0.38) | PFKFB3PFKFB4ALDH1A1MAPK1SLC2A1 | |
| SCHEMBL3683997 | 0.91 | ESR1 (0.35) | ALDH1A1ESR1CMA1SMN1; SMN2 | |
| SCHEMBL13508363 | 0.90 | F9 (0.36) | ALDH1A1MAPK1ESR1MAPT | |
| SCHEMBL13508292 | 0.88 | MAPT (0.39) | PFKFB3PFKFB4ALDH1A1SLC2A1CMA1 | |
| SCHEMBL3683627 | 0.84 | PPARD (0.41) | PFKFB3PFKFB4SLC2A1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |