Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylene Blue Cation. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.55 |
| ▸ | TERT | O14746 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Blue Cation SCHEMBL29474195 | 1.00 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL4565666 | 1.00 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1535728 | 0.98 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL31038651 | 0.98 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1535732 | 0.98 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1207311 | 0.98 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1462448 | 0.98 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312491 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL109755 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312498 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 133461 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144585-A1 | TIGHTLY TARGETED MINIMALLY INVASIVE (TTMIT) HYPERFUNCTIONING TISSUE ABLATING INSTRUMENT SYSTEM | Schwartz, Alan N. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4749288-A1 | COMPOSITIONS FOR DETECTING, CHARACTERIZING, AND REMOVING A BIOFILM | COSA Group GmbH (DE) | 2026-05-27 | — | — | EP | claimed |
| EP-4746915-A1 | TRIM21-BINDING MOLECULES | United Kingdom Research and Innovation (GB) | 2026-05-27 | — | — | EP | claimed |
| EP-4748304-A2 | SYSTEM AND METHOD FOR IDENTIFYING BLOOD VESSELS DURING FLUORESCENCE IMAGING | Perfusion Tech ApS (DK) | 2026-05-27 | — | — | EP | claimed |
| EP-4746828-A1 | ISOTROPIC SURGICAL IMPLANTS WITH FLOW-DEPOSITED CERAMIC PARTICLES | Orthomod LLC (US) | 2026-05-27 | — | — | EP | claimed |
| US-12636383-B2 | Methods of applying preparations of dyes and hydrogels to a tissue | KORCZYKOWSKI, Marc (US) | 2026-05-26 | — | — | US | claimed |
| CN-122079928-A | Preparation and application of methylene blue intermediate | — | 2026-05-26 | — | — | CN | claimed |
| CN-122076471-A | Metal basic salt mineralized membrane, preparation method thereof and application of metal basic salt mineralized membrane serving as heterogeneous catalyst in treatment of organic wastewater | — | 2026-05-26 | — | — | CN | claimed |
| CN-117607222-B | Cryptococcus rapid electric cracking and high-sensitivity electrochemical nucleic acid detection micro-platform and application | BEIHANG UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-120865466-B | Resin catalyst for synthesizing CPME, and preparation method and application thereof | DANDONG MINGZHU SPECIAL RESIN Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-3989740-A | ESTERIFICATION | CELANESE CORPORATION (US) | 1976-11-02 | — | — | US | claimed |
| US-3981683-A | FOR USE IN AUTOCLAVE | BIO-MEDICAL SCIENCES, INC. (US) | 1976-09-21 | — | — | US | claimed |
| US-3963580-A | COLORIMETRIC OXIDATION | MICROLIFE TECHNICS, INC. (US) | 1976-06-15 | — | — | US | claimed |
| US-3960658-A | RAPID IDENTIFICATION OF UROPATHOGENIC BACTERIA | CENTAUR CHEMICAL CO. (US) | 1976-06-01 | — | — | US | claimed |
| US-3957347-A | Selectively variable circularly dichroic filtering method | XEROX CORPORATION (US) | 1976-05-18 | — | — | US | claimed |
| US-3957348-A | Method for altering elliptically polarized light | XEROX CORPORATION (US) | 1976-05-18 | — | — | US | claimed |
| US-3957344-A | Information transfer system | XEROX CORPORATION (US) | 1976-05-18 | — | — | US | claimed |
| US-3953291-A | IMMOBILIZED ENZYMES | TANABE SEIYAKU CO., LTD. (JA) | 1976-04-27 | — | — | US | claimed |
| US-3935008-A | Electrophotographic process having developed hydrophilic image areas | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-01-27 | — | — | US | claimed |
| US-3933788-A | Polysaccharide and bacterial fermentation process for its preparation | KELCO COMPANY (US) | 1976-01-20 | — | — | US | claimed |