Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylene Blue Cation. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.53 |
| ▸ | TERT | O14746 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TST | Q16762 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Blue Cation SCHEMBL1535732 | 1.00 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1207311 | 1.00 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1535728 | 1.00 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL31038651 | 1.00 | APP (0.53) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1461350 | 0.98 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1351 | 0.98 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL29474195 | 0.98 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL4565666 | 0.98 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312498 | 0.96 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312497 | 0.96 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792254-B1 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES | WISTA LAB LTD (SG) | 2023-07-26 | — | — | EP | claimed |
| EP-3792254-A1 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES | WisTa Laboratories Ltd. (SG) | 2021-03-17 | — | — | EP | claimed |
| EP-3378856-B1 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES | WISTA LAB LTD (SG) | 2020-12-02 | — | — | EP | claimed |
| EP-3378856-A2 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES | WisTa Laboratories Ltd. (SG) | 2018-09-26 | — | — | EP | claimed |
| EP-2480540-B1 | METHYLTHIONINIUM CHLORIDE PENTAHYDRATE, PREPARATION AND PHARMACEUTICAL USE THEREOF | WISTA LAB LTD (SG) | 2017-11-29 | — | — | EP | claimed |
| EP-2963024-A2 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES - PART 2 | WisTa Laboratories Ltd. (SG) | 2016-01-06 | — | — | EP | claimed |
| US-8901296-B2 | Process for the preparation of substantially pure methylthionium chloride pentahydrate form A | WISTA LABORATORIES LTD. (SG) | 2014-12-02 | — | — | US | claimed |
| US-8765742-B2 | Crystalline methylthioninium chloride hydrates | WISTA LABORATORIES LTD. (SG) | 2014-07-01 | — | — | US | claimed |
| US-20120289499-A1 | PROCESS | WISTA LABORATORIES LTD. | 2012-11-15 | — | — | US | claimed |
| US-20120238556-A1 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES | WISTA LABORATORIES LTD. | 2012-09-20 | — | — | US | claimed |
| EP-2480540-A2 | PROCESS | Wista Laboratories Ltd. (SG) | 2012-08-01 | — | — | EP | claimed |
| EP-2480541-A2 | CRYSTALLINE METHYLTHIONIUM CHLORIDE (METHYLENE BLUE) HYDRATES | Wista Laboratories Ltd. (SG) | 2012-08-01 | — | — | EP | claimed |
| WO-2011036558-A9 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES | WISTA LABORATORIES LTD. (SG) | 2011-08-04 | — | — | WO | claimed |
| WO-2011036558-A2 | CRYSTALLINE METHYLTHIONIUM CHLORIDE (METHYLENE BLUE) HYDRATES | WISTA LABORATORIES LTD. (SG) | 2011-03-31 | — | — | WO | claimed |
| WO-2011036561-A2 | PROCESS | Wis Ta Laboratories Ltd. (SG) | 2011-03-31 | — | — | WO | claimed |
| EP-3792254-B1 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES | WISTA LAB LTD (SG) | 2023-07-26 | — | — | EP | disclosed |
| EP-3792254-A1 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES | WisTa Laboratories Ltd. (SG) | 2021-03-17 | — | — | EP | disclosed |
| WO-2011036558-A2 | CRYSTALLINE METHYLTHIONIUM CHLORIDE (METHYLENE BLUE) HYDRATES | WISTA LABORATORIES LTD. (SG) | 2011-03-31 | — | — | WO | disclosed |
| WO-2011036561-A2 | PROCESS | Wis Ta Laboratories Ltd. (SG) | 2011-03-31 | — | — | WO | disclosed |
| WO-2011036561-A2 | PROCESS | Wis Ta Laboratories Ltd. (SG) | 2011-03-31 | — | — | WO | disclosed |