Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | C1S | P09871 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14048213 | 0.79 | MAPT (0.61) | MAPTMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL19626670 | 0.79 | C1S (0.46) | MAPTALDH1A1KDM4ETSHRC1S | |
| SCHEMBL13513657 | 0.78 | KMT2A (0.59) | MAPTMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL2762871 | 0.77 | ALDH1A1 (0.55) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL19679620 | 0.76 | KMT2A (0.56) | MAPTMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL19625513 | 0.75 | C1S (0.44) | MAPTALDH1A1C1SKDM1ACYP11B1 | |
| SCHEMBL1916379 | 0.74 | NPC1 (0.58) | MAPTMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL1915608 | 0.74 | AR (0.56) | MAPTMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL1914839 | 0.74 | HSD17B10 (0.60) | MAPTMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL11499089 | 0.74 | MEN1 (0.55) | MAPTMEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575502-B1 | COMPOSITIONS AND METHODS INVOLVING NUCLEAR HORMONE RECEPTOR SITE II | BRISTOL MYERS SQUIBB CO (US) | 2010-01-20 | — | — | EP | disclosed |
| US-7442554-B2 | Compositions and methods involving glucocorticoid receptor site II | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-28 | — | — | US | disclosed |