Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL13518780 | 1.00 | LTA4H (0.41) | LTA4HFFAR1ITGB3ITGA2BFFAR4 | |
| Arginine SCHEMBL13519168 | 1.00 | LTA4H (0.41) | LTA4HFFAR1ITGB3ITGA2BFFAR4 | |
| Arginine SCHEMBL13518762 | 1.00 | LTA4H (0.41) | LTA4HFFAR1ITGB3ITGA2BFFAR4 | |
| Phenethylamine SCHEMBL13518878 | 0.95 | FFAR1 (0.42) | FFAR1ITGB3ITGA2BFFAR4PLAAT3 | |
| Phenethylamine SCHEMBL13518822 | 0.95 | FFAR1 (0.42) | FFAR1ITGB3ITGA2BFFAR4PLAAT3 | |
| Arginine SCHEMBL13518792 | 0.95 | LTA4H (0.40) | LTA4HITGB3ITGA2BPLAAT3PLAAT5 | |
| Arginine SCHEMBL13519205 | 0.95 | LTA4H (0.40) | LTA4HITGB3ITGA2BPLAAT3PLAAT5 | |
| Arginine SCHEMBL13518734 | 0.95 | LTA4H (0.40) | LTA4HITGB3ITGA2BPLAAT3PLAAT5 | |
| Arginine SCHEMBL13518702 | 0.95 | LTA4H (0.40) | LTA4HITGB3ITGA2BPLAAT3PLAAT5 | |
| Arginine SCHEMBL1661006 | 0.93 | LTA4H (0.40) | LTA4HITGB3ITGA2BPRSS1TMPRSS15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277164-A1 | GADD45BETA TARGETING AGENTS | IMPERIAL INNOVATIONS LIMITED (GB) | 2012-11-01 | — | — | US | claimed |
| US-8993717-B2 | Gadd45beta targeting agents | IMPERIAL INNOVATIONS LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-8771946-B2 | PKD mutations and evaluation of same | ATHENA DIAGNOSTICS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20120277164-A1 | GADD45BETA TARGETING AGENTS | IMPERIAL INNOVATIONS LIMITED (GB) | 2012-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277164-A1 | GADD45BETA TARGETING AGENTS | DDB1, CCL2, DDIT3 | LTA4H 3394/4885FFAR1 3984/4885ITGB3 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.