Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13888272 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3MAPTKMT2A | |
| SCHEMBL13200866 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3MAPTKMT2A | |
| SCHEMBL2966787 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3MAPTKMT2A | |
| SCHEMBL2966785 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3MAPTKMT2A | |
| SCHEMBL13868721 | 0.78 | DRD2 (0.46) | DRD2DRD4DRD3KDM4EGAA | |
| SCHEMBL13200867 | 0.78 | DRD2 (0.48) | DRD2DRD4DRD3MAPTMAPK1 | |
| SCHEMBL2961705 | 0.78 | DRD2 (0.48) | DRD2DRD4DRD3MAPTMAPK1 | |
| SCHEMBL2961702 | 0.78 | DRD2 (0.48) | DRD2DRD4DRD3MAPTMAPK1 | |
| SCHEMBL13888187 | 0.78 | DRD2 (0.48) | DRD2DRD4DRD3MAPTMAPK1 | |
| SCHEMBL13888287 | 0.76 | DRD2 (0.46) | DRD2DRD4DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1935887-B1 | Heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands | AVENTIS PHARMA INC (US) | 2010-01-13 | — | — | EP | disclosed |