Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 14/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.50 |
| ▸ | AURKA | O14965 | 7/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13524510 | 0.84 | PDPK1 (0.50) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL13524506 | 0.84 | PDPK1 (0.50) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL13525178 | 0.82 | JAK2 (0.52) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL13524501 | 0.82 | PDPK1 (0.48) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL84573 | 0.81 | PDPK1 (0.55) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL3166860 | 0.79 | JAK2 (0.49) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL13524469 | 0.78 | PDPK1 (0.66) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL6478211 | 0.77 | JAK2 (0.78) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL13524487 | 0.74 | PDPK1 (0.60) | PDPK1TGFBR1AURKAAURKBJAK2 | |
| SCHEMBL13524475 | 0.73 | JAK2 (0.54) | PDPK1TGFBR1AURKAAURKBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645799-B2 | Substituted biaryl compounds as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-01-12 | — | — | US | disclosed |
| US-20090062287-A1 | SUBSTITUTED BIARYL COMPOUNDS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-03-05 | — | — | US | disclosed |
| US-7459564-B2 | Substituted biaryl compounds as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062287-A1 | SUBSTITUTED BIARYL COMPOUNDS AS FACTOR XIA INHIBITORS | TFPI, F3, F12 | PDPK1 1904/4885TGFBR1 983/4885AURKA 543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.