Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 13/20 | 0.48 |
| ▸ | AURKA | O14965 | 7/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13525282 | 0.83 | PDPK1 (0.51) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL4491195 | 0.83 | DHFR (0.60) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL4481983 | 0.82 | HDAC6 (0.58) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL13524510 | 0.82 | PDPK1 (0.50) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL13524506 | 0.82 | PDPK1 (0.50) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL13524504 | 0.82 | PDPK1 (0.50) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL3167148 | 0.81 | JAK2 (0.46) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL13524497 | 0.81 | JAK2 (0.52) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL4494105 | 0.80 | SCN5A (0.62) | PDPK1AURKATGFBR1AURKBROCK1 | |
| SCHEMBL84573 | 0.79 | PDPK1 (0.55) | PDPK1AURKATGFBR1AURKBROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645799-B2 | Substituted biaryl compounds as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-01-12 | — | — | US | disclosed |
| US-20090062287-A1 | SUBSTITUTED BIARYL COMPOUNDS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-03-05 | — | — | US | disclosed |
| US-7459564-B2 | Substituted biaryl compounds as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062287-A1 | SUBSTITUTED BIARYL COMPOUNDS AS FACTOR XIA INHIBITORS | TFPI, F3, F12 | PDPK1 1904/4885AURKA 543/4885TGFBR1 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.