Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.50 |
| ▸ | CDK2 | P24941 | 10/20 | 0.50 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.46 |
| ▸ | CDK4 | P11802 | 5/20 | 0.46 |
| ▸ | CCND1 | P24385 | 5/20 | 0.46 |
| ▸ | CDK9 | P50750 | 5/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84453 | 0.84 | IKBKB (0.54) | IKBKBCCNE1CDK2EIF2AK4CCNT1 | |
| SCHEMBL91448 | 0.83 | IKBKB (0.52) | IKBKBCCNE1CDK2CCNT1CDK4 | |
| SCHEMBL13524640 | 0.81 | HRH4 (0.42) | IKBKBCCNE1CDK2JAK2JAK3 | |
| SCHEMBL3647868 | 0.78 | IKBKB (0.63) | IKBKBCCNE1CDK2EIF2AK4CDK4 | |
| SCHEMBL3647310 | 0.78 | IKBKB (0.63) | IKBKBCCNE1CDK2EIF2AK4CDK4 | |
| SCHEMBL4510051 | 0.78 | KCNH2 (0.61) | IKBKBCCNE1CDK2CCNT1CDK4 | |
| SCHEMBL91487 | 0.77 | CYP3A4 (0.47) | CDK2JAK2JAK3MAPK3 | |
| SCHEMBL15829853 | 0.77 | KDM4E (0.55) | IKBKBCCNE1CDK2JAK2JAK3 | |
| SCHEMBL12367075 | 0.76 | IKBKB (0.61) | IKBKBCCNE1CDK2CDK4CCND1 | |
| SCHEMBL15185727 | 0.76 | MAPK1 (0.50) | IKBKBCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | IKBKB 541/4885CCNE1 353/4885CDK2 20/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | IKBKB 345/4885CCNE1 487/4885CDK2 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.