Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | HPGD | P15428 | 7/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | ITGB3 | P05106 | 1/20 | 1.00 |
| ▸ | ITGA2B | P08514 | 1/20 | 1.00 |
| ▸ | HMGB1 | P09429 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | GGT1 | P19440 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL1331740 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL29350479 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL10456693 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL7580 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL21722099 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL20484785 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL4303603 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL21488922 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL21328429 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL7762350 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 784747 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444385-B1 | — | — | None | — | — | US | claimed |
| EP-2280983-B9 | C-ARYL GLYCOSIDE COMPOUNDS FOR THE TREATMENT OF DIABETES AND OBESITY | TFCHEM (FR) | 2021-06-09 | — | — | EP | claimed |
| US-9974992-B2 | Fire extinguishing composition comprising carboxylic acid derivative | XI'AN WESTPEACE FIRE TECHNOLOGY CO., LTD. (CN) | 2018-05-22 | — | — | US | claimed |
| US-9978565-B2 | Systems for cooling RF heated chamber components | LAM RESEARCH CORPORATION (US) | 2018-05-22 | — | — | US | claimed |
| US-9978475-B2 | Production method for conductive resin composition, and conductive resin composition | DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) | 2018-05-22 | — | — | US | claimed |
| US-20180134030-A1 | METHOD FOR PREPARING FLEXOGRAPHIC PRINTING PLATES | EASTMAN KODAK COMPANY | 2018-05-17 | — | — | US | claimed |
| US-20180134902-A1 | AIR FLOW GENERATING DEVICE, GRAPHENE DISPERSION, AND PREPARATION METHOD THEREOF | TAIWAN TEXTILE RESEARCH INSTITUTE (TW) | 2018-05-17 | — | — | US | claimed |
| US-20180136193-A1 | METHOD AND APPARATUS FOR DETERMINING MARKERS OF HEALTH BY ANALYSIS OF BLOOD | COR HEALTH, INC. | 2018-05-17 | — | — | US | claimed |
| US-20180138589-A1 | COMPOSITE METAMATERIAL, METHOD OF MANUFACTURE, AND USES THEREOF | ROGERS CORPORATION | 2018-05-17 | — | — | US | claimed |
| US-20180134870-A1 | PLASTICIZER COMPOSITION | SCG CHEMICAL CO., LTD. (TH) | 2018-05-17 | — | — | US | claimed |
| US-3935326-A | Process for coating tablets with aqueous resin dispersions | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-01-27 | — | — | US | claimed |
| US-3933552-A | Preparing transparent assemblies for lamination | PPG INDUSTRIES, INC. (US) | 1976-01-20 | — | — | US | claimed |
| US-3933055-A | Tensioning device for a flexible drive element | DEERE & COMPANY (US) | 1976-01-20 | — | — | US | claimed |
| US-3933509-A | Photo-polymerizable composition containing an acid salt of an indolinobenzospiropyran | FUJI PHOTO FILM CO., LTD. (JA) | 1976-01-20 | — | — | US | claimed |
| US-3933426-A | 1,3-DIMETHYLOL-4,5-DIHYDROXY-ETHYLENEUREA, OR ETHERS, ACID CATALYST, ALKALI METAL HALIDE | CIBA-GEIGY CORPORATION (US) | 1976-01-20 | — | — | US | claimed |
| US-3933319-A | Vertical spindle winder | ALLIED CHEMICAL CORPORATION (US) | 1976-01-20 | — | — | US | claimed |
| US-3932462-A | Manufacture of unsaturated ketones | BASF AKTIENGESELLSCHAFT (DT) | 1976-01-13 | — | — | US | claimed |
| US-3930419-A | Casing for shafts and cables | GENERAL ELECTRIC COMPANY (US) | 1976-01-06 | — | — | US | claimed |
| US-3930657-A | Device for sealing between preferably movable parts | SKEGA AKTIEBOLAG (SW) | 1976-01-06 | — | — | US | claimed |
| US-3930972-A | PROCESS FOR PREPARING THERMALLY STABILIZED OXYMETHYLENE POLYMER FROM TRIOXANE WITH THIOCYANATE AND RADIATION | JAPAN ATOMIC ENERGY RESEARCH INSTITUTE (JA) | 1976-01-06 | — | — | US | claimed |