Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | HPGD | P15428 | 7/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | ITGB3 | P05106 | 1/20 | 1.00 |
| ▸ | ITGA2B | P08514 | 1/20 | 1.00 |
| ▸ | HMGB1 | P09429 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | GGT1 | P19440 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL1331740 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL1353 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL29350479 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL10456693 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL21722099 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL20484785 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL4303603 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL21488922 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL21328429 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 | |
| Aspirin SCHEMBL7762350 | 0.98 | KDM4E (0.96) | KDM4EHSD17B10ALDH1A1HPGDESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 490 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250017846-A1 | TOPICAL ANALGESICS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2025-01-16 | — | — | US | claimed |
| US-20230190499-A1 | ANTICOAGULANT COMPOUNDS AND METHODS AND DEVICES FOR THEIR USE | ELIXIR MEDICAL CORPORATION (US) | 2023-06-22 | — | — | US | claimed |
| WO-2018183089-A1 | COMPOSITIONS FOR TREATING AND/OR PREVENTING CANCER | BOSTON BIOMEDICAL, INC. (US) | 2018-10-04 | — | — | WO | claimed |
| US-20160250217-A1 | CRYSTALLINE FORM OF PEMIROLAST | RSPR PHARMA AB (SE) | 2016-09-01 | — | — | US | claimed |
| WO-2016109361-A2 | 3-FLUORO-BENZONITRILE INHIBITORS OF 11-BETA-HYDROXYLASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| US-20120329813-A1 | Pemirolast for the Treatment of Systemic Low Grade Inflammation | CARDOZ AB (SE) | 2012-12-27 | — | — | US | claimed |
| EP-2498779-A1 | PEMIROLAST FOR THE TREATMENT OF SYSTEMIC LOW GRADE INFLAMMATION | Cardoz AB (SE) | 2012-09-19 | — | — | EP | claimed |
| US-20120157415-A1 | New Crystalline Form of Pemirolast | CARDOZ AB (SE) | 2012-06-21 | — | — | US | claimed |
| WO-2010146348-A9 | CRYSTALLINE FORM OF PEMIROLAST | CARDOZ AB (SE) | 2012-05-03 | — | — | WO | claimed |
| EP-2443120-A2 | NEW CRYSTALLINE FORM OF PEMIROLAST | Cardoz AB (SE) | 2012-04-25 | — | — | EP | claimed |
| WO-2011058331-A1 | PEMIROLAST FOR THE TREATMENT OF SYSTEMIC LOW GRADE INFLAMMATION | CARDOZ AB (SE) | 2011-05-19 | — | — | WO | claimed |
| US-20110112188-A1 | Treatment of Inflammatory Conditions | DYNAMIS THERAPEUTICS, INC. | 2011-05-12 | — | — | US | claimed |
| US-20110071767-A1 | Hepatotoxicity Molecular Models | OCIMUM BIOSOLUNTIONS, INC. (IN) | 2011-03-24 | — | — | US | claimed |
| WO-2011027119-A1 | COMBINATION MEDICAMENT | SHAH, SUNIL (GB) | 2011-03-10 | — | — | WO | claimed |
| US-20110002990-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | ALTER DOMUS (US) LLC | 2011-01-06 | — | — | US | claimed |
| WO-2010146348-A2 | NEW CRYSTALLINE FORM OF PEMIROLAST | CARDOZ AB (SE) | 2010-12-23 | — | — | WO | claimed |
| WO-2010146341-A2 | NEW CRYSTALLINE FORM OF PEMIROLAST | CARDOZ AB (SE) | 2010-12-23 | — | — | WO | claimed |
| US-20100124550-A1 | AMIDE INHIBITORS OF RENIN | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | US | claimed |
| WO-2009007679-A2 | COMBINATION FOR USE IN THE TREATMENT OF ATHEROSCLEROSIS COMPRISING A MAST CELL INHIBITOR AND A THROMBOXANE A2 ANTAGONIST | CARDOZ AB (SE) | 2009-01-15 | — | — | WO | claimed |
| US-7300666-B2 | Mixture for transdermal delivery of low and high molecular weight compounds | JRX BIOTECHNOLOGY, INC. (US) | 2007-11-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100124550-A1 | AMIDE INHIBITORS OF RENIN | REN, ACE, AGTR2 | PTGS1 355/4885PTGS2 464/4885KDM4E 2631/4885 |
| US-20250017846-A1 | TOPICAL ANALGESICS | OPRK1, OPRL1, OPRM1 | PTGS1 113/4885PTGS2 127/4885KDM4E 4409/4885 |
| US-20110002990-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | CYP2B6, CYP3A43, CYP2D6 | PTGS1 428/4885PTGS2 599/4885KDM4E 1802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.