Theaflavin Monogallates

Theaflavin Monogallates

SCHEMBL13530896

O=C(O[C@@H]1Cc2c(O)cc(O)cc2OC1c1cc(O)c(=O)c2c(O)c(O)cc(C3Oc4cc(O)cc(O)c4CC3O)c2c1)c1cc(O)c(O)c(O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 4/20 1.00
KDM4E B2RXH2 5/20 0.90
MEN1 O00255 5/20 0.90
MAPT P10636 5/20 0.90
RECQL P46063 5/20 0.90
KMT2A Q03164 5/20 0.90
TDP1 Q9NUW8 5/20 0.90
USP2 O75604 4/20 0.90
ALOX15 P16050 4/20 0.90
APEX1 P27695 4/20 0.90
BLM P54132 4/20 0.90
HSD17B10 Q99714 4/20 0.90
CYP3A4 P08684 3/20 0.90
HPGD P15428 3/20 0.90
GALK1 P51570 3/20 0.90
SLCO1B3 Q9NPD5 3/20 0.90
SLCO1B1 Q9Y6L6 3/20 0.90
THRB P10828 2/20 0.90
CASP1 P29466 2/20 0.90
MAPK1 P28482 2/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Theaflavin Monogallates SCHEMBL13287115 1.00 BCL2 (1.00) BCL2KDM4EMEN1MAPTRECQL
Theaflavin Monogallates SCHEMBL12658745 1.00 BCL2 (1.00) BCL2KDM4EMEN1MAPTRECQL
Theaflavin Monogallates SCHEMBL29477156 1.00 BCL2 (1.00) BCL2KDM4EMEN1MAPTRECQL
Theaflavin Monogallates SCHEMBL12240727 1.00 BCL2 (1.00) BCL2KDM4EMEN1MAPTRECQL
Theaflavin Monogallates SCHEMBL13300888 1.00 BCL2 (1.00) BCL2KDM4EMEN1MAPTRECQL
Theaflavin Monogallates SCHEMBL12792869 1.00 BCL2 (1.00) BCL2KDM4EMEN1MAPTRECQL
Theaflavin Monogallates SCHEMBL13300897 1.00 BCL2 (1.00) BCL2KDM4EMEN1MAPTRECQL
Theaflavin Monogallates SCHEMBL12672616 1.00 BCL2 (1.00) BCL2KDM4EMEN1MAPTRECQL
SCHEMBL17206998 0.98 BCL2 (0.97) BCL2KDM4EMEN1MAPTRECQL
SCHEMBL16440592 0.98 BCL2 (0.97) BCL2KDM4EMEN1MAPTRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9101656-B2 Use of tea-derived, theaflavin enriched extract to increase exercise performance and reduce exercise recovery time RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2015-08-11 US disclosed
US-8563047-B2 Use of tea-derived, theaflavin enriched extract to increase exercise performance and reduce exercise recovery time RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2013-10-22 US disclosed
US-20100015254-A1 Use of tea-derived, theaflavin enriched extract to increase exercise performance and reduce exercise recovery time STATE UNIVERSITY OF NEW JERSEY RUTGERS, THE 2010-01-21 US disclosed
US-20090092690-A1 Process of making theaflavins enriched tea extract GUILIN LAYN NATURAL INGREDIENTS CORP. (CN) 2009-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090092690-A1 Process of making theaflavins enriched tea extract TEAD4, TEAD1, TEAD2 BCL2 4229/4885KDM4E 880/4885MEN1 3707/4885
US-20100015254-A1 Use of tea-derived, theaflavin enriched extract to increase exercise performance and reduce exercise recovery time TES, TEAD3, CPT1B BCL2 3486/4885KDM4E 2800/4885MEN1 4645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.