Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 10/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13533458 | 0.83 | TLR7 (0.69) | YTHDC1ADORA2APDE4DPDE4APDE4B | |
| SCHEMBL13533465 | 0.83 | IKBKB (0.50) | YTHDC1ADORA2APDE4DPDE4APDE4B | |
| SCHEMBL13533460 | 0.82 | IKBKB (0.49) | YTHDC1ADORA2APDE4DPDE4APDE4B | |
| SCHEMBL14537690 | 0.81 | ADORA3 (0.44) | YTHDC1ADORA2APDE4DPDE4APDE4B | |
| SCHEMBL9601993 | 0.81 | CYP11B1 (0.50) | YTHDC1ADORA2APDE4DPDE4ATLR7 | |
| SCHEMBL13533472 | 0.80 | IKBKB (0.47) | YTHDC1ADORA2APDE4DPDE4APDE4B | |
| SCHEMBL13533468 | 0.80 | IKBKB (0.47) | YTHDC1ADORA2APDE4DPDE4APDE4B | |
| SCHEMBL3188618 | 0.80 | TLR7 (0.67) | ADORA2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL9199346 | 0.80 | CYP11B1 (0.53) | ADORA2APDE4DPDE4ATLR7LMNA | |
| SCHEMBL9602894 | 0.79 | TLR7 (0.51) | YTHDC1ADORA2APDE4DIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567329-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-c]quinolin-4-amines and 1H-imidazo[4,5-c]quinolin-4-amine-related compounds and uses thereof | TECHFIELDS PHARMA CO., LTD. (CN) | 2017-02-14 | — | — | US | disclosed |
| US-9567329-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-c]quinolin-4-amines and 1H-imidazo[4,5-c]quinolin-4-amine-related compounds and uses thereof | TECHFIELDS PHARMA CO., LTD. (CN) | 2017-02-14 | — | — | US | disclosed |
| US-20130131100-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS AND USES THEREOF | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-05-23 | — | — | US | disclosed |
| US-20130131100-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS AND USES THEREOF | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-05-23 | — | — | US | disclosed |
| US-8349866-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-C]quinolin-4-amines and 1H-imidazo[4,5-C]quinolin-4-amine-related compounds | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-01-08 | — | — | US | disclosed |
| US-8349866-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-C]quinolin-4-amines and 1H-imidazo[4,5-C]quinolin-4-amine-related compounds | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-01-08 | — | — | US | disclosed |
| US-20100021394-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS | PREMIER RESEARCH INTERNATIONAL, LLC | 2010-01-28 | — | — | US | disclosed |
| US-20100021394-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS | PREMIER RESEARCH INTERNATIONAL, LLC | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131100-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS AND USES THEREOF | HRH4, SLC7A1, ABCG2 | YTHDC1 3095/4885ADORA2A 354/4885PDE4D 747/4885 |
| US-20100021394-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS | SLC7A1, HRH4, CYP3A4 | YTHDC1 2873/4885ADORA2A 382/4885PDE4D 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.