Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.81 |
| ▸ | ESR1 | P03372 | 1/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.81 |
| ▸ | HTR1A | P08908 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.81 |
| ▸ | HPGD | P15428 | 1/20 | 0.81 |
| ▸ | MAOA | P21397 | 1/20 | 0.81 |
| ▸ | DRD1 | P21728 | 1/20 | 0.81 |
| ▸ | ACHE | P22303 | 1/20 | 0.81 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.81 |
| ▸ | PDE4A | P27815 | 1/20 | 0.81 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.81 |
| ▸ | DRD3 | P35462 | 1/20 | 0.81 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimetrexate SCHEMBL3983 | 0.90 | DHFR (1.00) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL29376841 | 0.90 | DHFR (1.00) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL29403928 | 0.90 | DHFR (1.00) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL10701228 | 0.90 | DHFR (1.00) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL539115 | 0.90 | DHFR (0.86) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL29906169 | 0.89 | DHFR (0.98) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL7099831 | 0.89 | DHFR (0.98) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL7099341 | 0.89 | DHFR (0.98) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL8035980 | 0.88 | DHFR (0.96) | DHFRMEN1ALDH1A1ESR1CHRM2 | |
| Trimetrexate SCHEMBL8922992 | 0.86 | DHFR (0.76) | DHFRMEN1ALDH1A1ESR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8617831-B2 | Methods for diagnosing and monitoring the progression of cancer by measuring soluble c-Met ectodomain | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-12-31 | — | — | US | disclosed |
| US-20130029352-A1 | METHODS FOR DIAGNOSING AND MONITORING THE PROGRESSION OF CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-01-31 | — | — | US | disclosed |
| US-8304199-B2 | Methods for diagnosing and monitoring the progression of cancer by measuring soluble c-Met ectodomain | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-11-06 | — | — | US | disclosed |
| US-20110287450-A1 | Methods For Diagnosing And Monitoring The Progression Of Cancer | AMGEN, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-7964365-B2 | Methods for diagnosing and monitoring the progression of cancer | The United States of Americam as represented by the Secretary, Department of Health and Human Services (US) | 2011-06-21 | — | — | US | disclosed |
| US-20080286825-A1 | Methods for Diagnosing and Monitoring the Progression of Cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2008-11-20 | — | — | US | disclosed |
| WO-2007056523-A2 | METHODS FOR DIAGNOSING AND MONITORING THE PROGRESSION OF CANCER | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007025031-A2 | PRODRUGS OF INDANONE AND TETRALONE COMPOUNDS | CEPHALON, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| EP-1735448-A2 | INDUCIBLE DIMERIZATION OF GROWTH FACTOR RECEPTORS FOR TREATING CANCER | The University of Washington (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005110491-A2 | INDUCIBLE DIMERIZATION OF GROWTH FACTOR RECEPTORS FOR TREATING CANCER | UNIVERSITY OF WASHINGTON (US) | 2005-11-24 | — | — | WO | disclosed |
| US-20050238628-A1 | Methods for treating cancer | THE UNIVERSITY OF WASHINGTON | 2005-10-27 | — | — | US | disclosed |