Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 3/20 | 0.46 |
| ▸ | CPA3 | P15088 | 3/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | CPB1 | P15086 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11599447 | 0.88 | CYP1A2 (0.63) | CYP1A2PPARGSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL21895912 | 0.84 | CYP1A2 (0.67) | CYP1A2PKMPPARGSLC1A3SLC1A2 | |
| SCHEMBL11634382 | 0.84 | CYP1A2 (0.67) | CYP1A2PKMPPARGSLC1A3SLC1A2 | |
| SCHEMBL9297390 | 0.83 | PPARG (0.61) | MAPTKDM4EALDH1A1PPARG | |
| SCHEMBL13535263 | 0.83 | MAPT (0.52) | MAPTCYP1A2KDM4EPKMALDH1A1 | |
| SCHEMBL28040970 | 0.82 | CYP1A2 (0.64) | CYP1A2PKMPPARGSLC1A3SLC1A2 | |
| SCHEMBL497369 | 0.82 | CYP1A2 (0.68) | CYP1A2PKMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL28126947 | 0.81 | CYP1A2 (0.57) | CYP1A2CPA1ACE | |
| SCHEMBL4724923 | 0.80 | CYP1A2 (0.65) | CYP1A2PKMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL40705 | 0.80 | CYP1A2 (0.65) | CYP1A2PKMSLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7649015-B2 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | GILEAD SCIENCES, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | PPA1, PNP, PPME1 | MAPT 1076/4885CYP1A2 4360/4885KDM4E 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.