Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 10/20 | 0.67 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 5/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535484 | 0.85 | JAK1 (0.66) | JAK1ABL1JAK2TYK2 | |
| SCHEMBL13535405 | 0.84 | JAK1 (0.72) | JAK1JAK2 | |
| SCHEMBL13535479 | 0.83 | JAK1 (0.71) | JAK1JAK2 | |
| SCHEMBL13535409 | 0.82 | JAK1 (0.70) | JAK1ABL1JAK2 | |
| SCHEMBL3266576 | 0.82 | JAK1 (0.70) | JAK1JAK2 | |
| SCHEMBL13535530 | 0.82 | JAK1 (0.82) | JAK1JAK2TYK2 | |
| SCHEMBL2237872 | 0.81 | JAK1 (0.68) | JAK1JAK2 | |
| SCHEMBL13535464 | 0.81 | JAK1 (0.68) | JAK1JAK2 | |
| SCHEMBL13535427 | 0.81 | JAK1 (0.68) | JAK1JAK2 | |
| SCHEMBL13535389 | 0.81 | JAK1 (0.67) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010186-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |