Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 7/20 | 0.46 |
| ▸ | JAK2 | O60674 | 8/20 | 0.45 |
| ▸ | BRD4 | O60885 | 8/20 | 0.45 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | BRD2 | P25440 | 2/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535980 | 0.88 | PTK2 (0.46) | PTK2JAK2JAK1JAK3 | |
| SCHEMBL3261610 | 0.83 | JAK1 (0.53) | PTK2JAK2JAK1JAK3 | |
| SCHEMBL13535729 | 0.82 | JAK2 (0.60) | PTK2JAK2JAK1JAK3 | |
| SCHEMBL13536043 | 0.81 | JAK2 (0.49) | PTK2JAK2JAK1JAK3 | |
| SCHEMBL13536042 | 0.80 | JAK2 (0.49) | PTK2JAK2BRD4JAK1JAK3 | |
| SCHEMBL13535979 | 0.72 | JAK2 (0.64) | PTK2JAK2JAK1JAK3 | |
| SCHEMBL13535598 | 0.72 | JAK2 (0.48) | PTK2JAK2JAK1JAK3 | |
| SCHEMBL3261143 | 0.72 | JAK2 (0.61) | PTK2JAK2JAK1JAK3 | |
| SCHEMBL13536000 | 0.72 | JAK2 (0.47) | PTK2JAK2JAK1JAK3 | |
| SCHEMBL13535589 | 0.71 | JAK2 (0.51) | PTK2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |