Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.65 |
| ▸ | JAK3 | P52333 | 7/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.58 |
| ▸ | JAK1 | P23458 | 5/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3194154 | 0.90 | JAK2 (0.69) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL13536591 | 0.90 | JAK2 (0.68) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL13536509 | 0.82 | JAK1 (0.61) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3263231 | 0.82 | JAK2 (0.77) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145769 | 0.80 | JAK2 (0.64) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL7977734 | 0.80 | JAK2 (0.72) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL7973523 | 0.80 | JAK2 (0.73) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL13536589 | 0.79 | JAK1 (0.66) | JAK2JAK3PTK2JAK1TYK2 | |
| SCHEMBL2640702 | 0.79 | JAK2 (1.00) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL15416898 | 0.79 | JAK2 (0.81) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |