Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20668153 | 0.83 | CYP2A6 (0.44) | SMN1; SMN2KDM4ETP53HSD17B10NPC1 | |
| SCHEMBL29496935 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4ETP53HSD17B10NPC1 | |
| SCHEMBL2039527 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4ETP53HSD17B10NPC1 | |
| SCHEMBL1445133 | 0.81 | CCNT1 (0.60) | KDM4EHSD17B10LMNATDP1CYP2A6 | |
| SCHEMBL28456060 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ETP53HSD17B10NPC1 | |
| SCHEMBL3898528 | 0.79 | IKBKB (0.47) | SMN1; SMN2KDM4ETP53HSD17B10NPC1 | |
| SCHEMBL31689354 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4ETP53HSD17B10NPC1 | |
| SCHEMBL12270012 | 0.77 | CYP2A6 (0.50) | CYP2A6SLC22A12CYP1A2CCR1CCR8 | |
| SCHEMBL5142866 | 0.77 | CYP2A6 (0.48) | SMN1; SMN2KDM4ETP53HSD17B10NPC1 | |
| SCHEMBL27892845 | 0.77 | GSK3B (0.48) | KDM4EGAALMNAPOLBCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344486-B1 | ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THEIR USE AS FAAH INHIBITORS | SANOFI SA (FR) | 2013-03-27 | — | — | EP | disclosed |
| WO-2010010288-A2 | ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-01-28 | — | — | WO | disclosed |