Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | CDK9 | P50750 | 1/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154563 | 0.82 | CCNT1 (0.52) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL30141974 | 0.82 | CCNT1 (0.52) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL30831604 | 0.82 | CCNT1 (0.52) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL13537102 | 0.81 | SMN1; SMN2 (0.49) | CYP1A2CYP2D6CYP2C19CYP2E1CYP2A6 | |
| Ammonia Solution, Strong SCHEMBL1121071 | 0.81 | CCNT1 (0.51) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL28135263 | 0.79 | CYP1A2 (0.51) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL1445782 | 0.79 | CYP1A2 (0.43) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL2997834 | 0.76 | CCNT1 (1.00) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL29941740 | 0.76 | CCNT1 (1.00) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL27534760 | 0.75 | CCNT1 (0.49) | CCNT1CCNA2CDK2CDK9CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480235-A2 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS | University Of Louisville Research Foundation, Inc. (US) | 2012-08-01 | — | — | EP | claimed |
| WO-2011038234-A2 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2011-03-31 | — | — | WO | claimed |