Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.48 |
| ▸ | PIM1 | P11309 | 6/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | ESRRA | P11474 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1579058 | 0.93 | PIM2 (0.49) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL12281665 | 0.93 | PIM2 (0.49) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL1579056 | 0.93 | PIM2 (0.49) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL13537611 | 0.90 | PIM2 (0.47) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL13537931 | 0.87 | PIM2 (0.43) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL13537785 | 0.86 | PIM2 (0.43) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL13537912 | 0.85 | PIM2 (0.41) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL12282863 | 0.84 | PIM2 (0.47) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL1580220 | 0.84 | PIM2 (0.47) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL1580219 | 0.84 | PIM2 (0.47) | PIM2PIM1PIM3IGF1RNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |