Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580232 | 0.94 | PIM2 (0.41) | PIM2PIM1PIM3HRH3HPGD | |
| SCHEMBL12282264 | 0.94 | PIM2 (0.41) | PIM2PIM1PIM3HRH3HPGD | |
| SCHEMBL1580235 | 0.94 | PIM2 (0.41) | PIM2PIM1PIM3HRH3HPGD | |
| SCHEMBL13537931 | 0.89 | PIM2 (0.43) | PIM2PIM1PIM3HRH3HPGD | |
| SCHEMBL13537625 | 0.85 | PIM2 (0.48) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL12281622 | 0.83 | PIM2 (0.43) | PIM2PIM1PIM3HRH3HPGD | |
| SCHEMBL2424046 | 0.83 | PIM2 (0.43) | PIM2PIM1PIM3HRH3HPGD | |
| SCHEMBL2424048 | 0.83 | PIM2 (0.43) | PIM2PIM1PIM3HRH3HPGD | |
| SCHEMBL13537785 | 0.82 | PIM2 (0.43) | PIM2PIM1PIM3HPGDIGF1R | |
| SCHEMBL13537913 | 0.82 | NR1H4 (0.39) | PIM2PIM1PIM3HRH3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |